From mappa mundi to lorem mappa: a retrospective of map communication

Maps as a means of visual communication date as far back as humans were able to sketch locations in the dirt. This presentation will, however, begin in the Middle Ages with the iconic mappa mundi. It can be argued that the mappa mundi predates the earliest maps in its apparent dismissal of real world accuracy, the intent being to communicate a summary of medieval knowledge. We know, however, that maps have always served several purposes, figurative and literal, ceremonial and practical. Contemporary maps are no exception. Examples of map communication models dating from the 1950s will be used to illustrate that maps, regardless of media or method, have not changed in purpose. The term lorem mappa will be introduced as a moniker for electronic or Internet-based maps. These lorem mappae, whether interactive, dynamic, static, or network-based, all serve to communicate place-based information. In spite of the technological framework on which many contemporary maps are based, the lorem mappa and the mappa mundi are more similar as vehicles of communication than conventional wisdom might suggest

Cost per User as Key Factor in Project Prioritization: A Case Study of the San Francisco Bay Area

Efforts to accommodate increasing and dispersed demand for travel in the face of mounting traffic congestion, escalating construction costs, limited rights of way, and diminished air quality have caused planning agencies to adopt plans that would enhance transit choices. Faced with fiscal limitations, the need to prioritize the ever-growing list of improvement projects is paramount. To meet this need in the development of the Bay Area System Plan for Regional Express Bus Service in California, a survey of existing literature on capital investment prioritization in transportation was conducted. This review led to development of a simple prioritization methodology with which to analyze the projects. Unit costs per ride were calculated to facilitate comparisons between the various proposals. The cost estimation procedure involved a systematic sequence of analyses that included the development and quantification of conceptual design elements, application of unit capital as well as operation and maintenance costs, and matching of annualized costs with annual ridership to derive costs per affected ride. Results revealed that the greater majority of proposed improvements could be implemented at a relatively low total cost. The estimates also suggest that most proposed improvements will not add very significant additional costs per ride to existing operations. The case study demonstrates the utility of projects and illustrates an approach that could be used by other agencies

MHC-linked and un-linked class I genes in the wallaby

Background: MHC class I antigens are encoded by a rapidly evolving gene family comprising classical and non-classical genes that are found in all vertebrates and involved in diverse immune functions. However, there is a fundamental difference between the organization of class I genes in mammals and non-mammals. Non-mammals have a single classical gene responsible for antigen presentation, which is linked to the antigen processing genes, including TAP. This organization allows co-evolution of advantageous class Ia/ TAP haplotypes. In contrast, mammals have multiple classical genes within the MHC, which are separated from the antigen processing genes by class III genes. It has been hypothesized that separation of classical class I genes from antigen processing genes in mammals allowed them to duplicate. We investigated this hypothesis by characterizing the class I genes of the tammar wallaby, a model marsupial that has a novel MHC organization, with class I genes located within the MHC and 10 other chromosomal locations. Results: Sequence analysis of 14 BACs containing 15 class I genes revealed that nine class I genes, including one to three classical class I, are not linked to the MHC but are scattered throughout the genome. Kangaroo Endogenous Retroviruses (KERVs) were identified flanking the MHC un-linked class I. The wallaby MHC contains four non-classical class I, interspersed with antigen processing genes. Clear orthologs of non-classical class I are conserved in distant marsupial lineages. Conclusion: We demonstrate that classical class I genes are not linked to antigen processing genes in the wallaby and provide evidence that retroviral elements were involved in their movement. The presence of retroviral elements most likely facilitated the formation of recombination hotspots and subsequent diversification of class I genes. The classical class I have moved away from antigen processing genes in eutherian mammals and the wallaby independently, but both lineages appear to have benefited from this loss of linkage by increasing the number of classical genes, perhaps enabling response to a wider range of pathogens. The discovery of non-classical orthologs between distantly related marsupial species is unusual for the rapidly evolving class I genes and may indicate an important marsupial specific function

On the relativistic Doppler effect for precise velocity determination using GPS

The Doppler effect is the apparent shift in frequency of an electromagnetic signal that is received by an observer moving relative to the source of the signal. The Doppler frequency shift relates directly to the relative speed between the receiver and the transmitter, and has thus been widely used in velocity determination. A GPS receiver-satellite pair is in the Earth's gravity field and GPS signals travel at the speed of light, hence both Einstein's special and general relativity theories apply. This paper establishes the relationship between a Doppler shift and a user's ground velocity by taking both the special and general relativistic effects into consideration. A unified Doppler shift model is developed, which accommodates both the classical Doppler effect and the relativistic Doppler effect under special and general relativities. By identifying the relativistic correction terms in the model, a highly accurate GPS Doppler shift observation equation is presented. It is demonstrated that in the GPS "frequency" or "velocity" domain, the relativistic effect from satellite motion changes the receiver-satellite line-of-sight direction, and the measured Doppler shift has correction terms due to the relativistic effects of the receiver potential difference from the geoid, the orbit eccentricity, and the rotation of the Earth

GPS satellite velocity and acceleration determination using the broadcast ephemeris

Satellite velocity determination using the broadcast ephemeris is discussed and it is pointed out that the conventional rotation matrix method involves a complicated process of computation. This paper proposes an alternative method using a simple differentiator to derive satellite Earth-Centred-Earth-Fixed (ECEF) velocity from the ECEF satellite positions that are calculated using the standard ICD-GPS-200 algorithm. The proposed algorithm simplifies the velocity transformation procedure, and therefore provides a good alternative. It is demonstrated that +/- 1 mm/s per axis ECEF satellite velocity is achievable by using the first-order central difference of a Taylor series approximation. A closed-form formula is also derived for the determination of GPS satellite ECEF acceleration using the broadcast ephemeris. This formula is capable of accuracies better than +/- 0.1 mm per second squared in each axis. With such a high accuracy of satellite acceleration in real-time, it is possible to detect the line-of-sight range acceleration precisely and as such it is concluded that a GPS receiver can be considered as a precise accelerometer. The success of the position differential method implies that real-time satellite ECEF velocities can be directly derived through numerical differentiation of the position polynomials. This is desirable for GPS velocity determination applications which require high output rate results in real-time. The derived closed-form formula for GPS satellite ECEF acceleration would benefit those who attempt to use a GPS receiver as an accurate accelerometer in real-time

Role of BacA in Lipopolysaccharide Synthesis, Peptide Transport, and Nodulation by \u3cem\u3eRhizobium\u3c/em\u3e sp. Strain NGR234

BacA of Sinorhizobium meliloti plays an essential role in the establishment of nitrogen-fixing symbioses with Medicago plants, where it is involved in peptide import and in the addition of very-long-chain fatty acids (VLCFA) to lipid A of lipopolysaccharide (LPS). We investigated the role of BacA in Rhizobium species strain NGR234 by mutating the bacA gene. In the NGR234 bacA mutant, peptide import was impaired, but no effect on VLCFA addition was observed. More importantly, the symbiotic ability of the mutant was comparable to that of the wild type for a variety of legume species. Concurrently, an acpXL mutant of NGR234 was created and assayed. In rhizobia, AcpXL is a dedicated acyl carrier protein necessary for the addition of VLCFA to lipid A. LPS extracted from the NGR234 mutant lacked VLCFA, and this mutant was severely impaired in the ability to form functional nodules with the majority of legumes tested. Our work demonstrates the importance of VLCFA in the NGR234-legume symbiosis and also shows that the necessity of BacA for bacteroid differentiation is restricted to specific legume-Rhizobium interactions

Partnership, ownership and control: the impact of corporate governance on employment relations

Prevailing patterns of dispersed share ownership and rules of corporate governance for UK listed companies appear to constrain the ability of managers to make credible, long-term commitments to employees of the kind needed to foster effective labour-management partnerships. We present case study evidence which suggests that such partnerships can nevertheless emerge where product market conditions and the regulatory environment favour a stakeholder orientation. Proactive and mature partnerships may also be sustained where the board takes a strategic approach to mediating between the claims of different stakeholder groups, institutional investors are prepared to take a long-term view of their holdings, and strong and independent trade unions are in a position to facilitate organisational change